Homeostatic Inflammation

Pioglitazone Reduces Vascular Lipid Accumulation in Angiotensin II-Induced Hypertensive Rat
Aim, In an insulin-resistant state, excess lipids may accumulate in various non-adipose tissues, leading to histological and functional …
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Endothelial PGC-1α mediates vascular dysfunction in diabetes
Endothelial dysfunction is a central hallmark of diabetes. The transcriptional coactivator PGC-1α is a powerful regulator of …
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HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9
Objective, Endogenous ligands such as high-mobility group box 1 (HMGB1) and nucleic acids are released by dying cells and bind to …
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Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1β upregulation via nuclear factor κB activation
Background, Inflammation is induced in the heart during the development of cardiac hypertrophy. The initiating mechanisms and the role …
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The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response
Objective, ATP-binding cassette transporter subfamily G member 2 (ABCG2), expressed in microvascular endothelial cells in the heart, …
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Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice
The efficacy of aliskiren, a direct renin inhibitor, in ventricular remodeling after myocardial infarction (MI) compared with …
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The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function
Objective, To clarify the impact of breast cancer resistance protein 1 (BCRP1)/ATP-binding cassette transporter subfamily G member 2 …
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Serum osteoprotegerin levels and long-term prognosis in subjects with stable coronary artery disease
Background, Osteoprotegerin (OPG) is a secretory glycoprotein which belongs to the tumor necrosis factor receptor family. OPG …
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Difference of culprit plaque composition between patients with and without pre-infarction angina: an intravascular ultrasound radiofrequency analysis
Aims, This study was performed to assess the differences in culprit plaque composition between patients with and without pre-infarction …
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Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice
The renin-angiotensin (Ang) system plays a critical role in the regulation of blood pressure, body fluid, electrolyte homeostasis, and …
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