Higashikuni Lab
Higashikuni Lab
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Automatic
Homeostatic Inflammation
Novel Therapeutic Strategy for Cardiovascular Disease
Based on our basic research findings and clinical experience, we will discuss next-generation therapeutic strategy for cardiovascular disease.
Nov 11, 2023 9:00 AM — 6:00 PM
Tokyo, Online
Yasutomi Higashikuni, M.D., Ph.D., FESC
Project
Project
Project
Heart Failure and Inflammation
We will discuss how inflammation is initiated in the stressed heart and causes heart failure.
Oct 30, 2023 6:00 PM — 7:30 PM
Tokyo, Online
Yasutomi Higashikuni, M.D., Ph.D., FESC
Project
Project
Sports Activity for Mens' Health in Cardiovascular Medicine
We will discuss how sports activity can contribute to men’s health in cardiovascular medicine.
Sep 10, 2023 9:00 AM — 10:30 AM
Tokyo
Yasutomi Higashikuni, M.D., Ph.D., FESC
Project
Not a small frog in a big pond: targeting bradykinin receptor B2 signaling in vascular smooth muscle cells for treatment of hypertension
not available.
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Wenhao Liu, M.D.
,
Masataka Sata
Project
DOI
Therapeutic Strategy for Hyperuricemia in Cardiovascular Medicine
Our basic research findings and clinical experience provide new insight into therapeutic strategy for hyperuricemia in patients with cardiovascular disease.
Jul 15, 2023 2:00 PM — 3:00 PM
Osaka
Yasutomi Higashikuni, M.D., Ph.D., FESC
Project
Optimizing antihypertensive therapy in patients with diabetes mellitus
not available.
Wenhao Liu, M.D.
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Masataka Sata
Project
DOI
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
Background, Mechanical stress on the heart, such as high blood pressure, initiates inflammation and causes hypertrophic heart disease. …
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Wenhao Liu, M.D.
,
Genri Numata
,
Kimie Tanaka
,
Daiju Fukuda
,
Yu Tanaka, M.D., Ph.D.
,
Yoichiro Hirata
,
Teruhiko Imamura
,
Eiki Takimoto
,
Issei Komuro
,
Masataka Sata
Project
DOI
Just published in Circulation!!
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
Yasutomi Higashikuni, M.D., Ph.D., FESC
Last updated on Dec 1, 2022
1 min read
Lab
Project
Hyperuricemia in Cardiovascular Medicine
Our basic research findings provide new insight into therapeutic strategy for hyperuricemia in patients with cardiovascular disease.
Nov 21, 2022 7:00 PM — 8:00 PM
Tokyo, Online
Yasutomi Higashikuni, M.D., Ph.D., FESC
Project
Endoplasmic reticulum stress-activated nuclear factor-kappa B signaling pathway induces the upregulation of cardiomyocyte dopamine D1 receptor in heart failure
Dopamine D1 receptor (D1R), coded by the Drd1 gene, is induced in cardiomyocytes of failing hearts, triggering heart failure-associated …
Shun Nakamura
,
Genri Numata
,
Toshihiro Yamaguchi
,
Hiroyuki Tokiwa
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Seitaro Nomura
,
Tetsuo Sasano
,
Eiki Takimoto
,
Issei Komuro
Project
DOI
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