Publications

Wenhao Liu, M.D., Yasutomi Higashikuni, M.D., Ph.D., FESC (2024). Self-DNA sensing in cigarette smoke-induced vascular inflammation: the role of mitochondrial DNA release in vascular endothelial cells. Hypertens Res. 2024 Mar;47:799-802.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Wenhao Liu, M.D., Masataka Sata (2024). Nocturnal blood pressure and left ventricular hypertrophy in patients with diabetes mellitus. Hypertens Res. 2024 Mar;47:819-822.

Shinnosuke Sawano, Mizuki Miura, Yasutomi Higashikuni, M.D., Ph.D., FESC, Hiroyuki Saigusa, Satoshi Kodera, Norifumi Takeda, Masaru Hatano, Jiro Ando, Minoru Ono, Issei Komuro (2023). Clinical valve thrombosis and arterial embolism in a cancer patient after transcatheter aortic valve replacement. Oxf Med Case Reports. 2023 Nov28;2023:omad125.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Wenhao Liu, M.D., Masataka Sata (2023). Not a small frog in a big pond: targeting bradykinin receptor B2 signaling in vascular smooth muscle cells for treatment of hypertension. Hypertens Res. 2023 Mar;46:2415-2418.

Susumu Katsushika, Satoshi Kodera, Shinnosuke Sawano, Hiroki Shinohara, Naoto Setoguchi, Kengo Tanabe, Yasutomi Higashikuni, M.D., Ph.D., FESC, Norifumi Takeda, Katsuhito Fujiu, Masao Daimon, Hiroshi Akazawa, Hiroyuki Morita, Issei Komuro (2023). An explainable artificial intelligence-enabled electrocardiogram analysis model for the classification of reduced left ventricular function. Eur Heart J Digit Health. 2023;4(3):254-264.

Wenhao Liu, M.D., Yasutomi Higashikuni, M.D., Ph.D., FESC, Masataka Sata (2023). Optimizing antihypertensive therapy in patients with diabetes mellitus . Hypertens Res. 2023 Mar;46(3):797-800.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Wenhao Liu, M.D., Genri Numata, Kimie Tanaka, Daiju Fukuda, Yu Tanaka, M.D., Ph.D., Yoichiro Hirata, Teruhiko Imamura, Eiki Takimoto, Issei Komuro, Masataka Sata (2023). NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload. Circulation. 2023 Jan 24;147(4):338-355.

Shun Nakamura, Genri Numata, Toshihiro Yamaguchi, Hiroyuki Tokiwa, Yasutomi Higashikuni, M.D., Ph.D., FESC, Seitaro Nomura, Tetsuo Sasano, Eiki Takimoto, Issei Komuro (2022). Endoplasmic reticulum stress-activated nuclear factor-kappa B signaling pathway induces the upregulation of cardiomyocyte dopamine D1 receptor in heart failure. Biochem Biophys Res Commun. 2022 Nov 14;637:247-253.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Wenhao Liu, M.D., Masataka Sata (2022). Give a Leg Up: Screening for Peripheral Artery Disease after Acute Myocardial Infarction. J Atheroscler Thromb. 2022 Jul 1;29(7):989-991.

Wenhao Liu, M.D., Yasutomi Higashikuni, M.D., Ph.D., FESC, Masataka Sata (2022). Linking RNA dynamics to heart disease: the lncRNA/miRNA/mRNA axis in myocardial ischemia-reperfusion injury. Hypertens Res. 2022 Jun;45(6):1067-1069.

Shinnosuke Sawano, Satoshi Kodera, Susumu Katsuhika, Mitsuhiko Nakamoto, Kota Ninomiya, Hiroki Shinohara, Yasutomi Higashikuni, M.D., Ph.D., FESC, Koki Nakanishi, Tomoko Nakao, Tomohisa Seki, Norifumi Takeda, Katsuhito Fujiu, Masao Daimon, Hiroshi Akazawa, Hiroyuki Morita, Issei Komuro (2022). Deep learning model to detect significant aortic regurgitation using electrocardiography. J Cardiol. 2022 Mar;79(3):334-341.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Wenhao Liu, M.D., Takumi Obana, Masataka Sata (2021). Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications. Int J Mol Sci. 2021 Nov 8;22(21):12081.

Hiroki Shinohara, Satoshi Kodera, Kota Ninomiya, Mitsuhiko Nakamoto, Susumu Katsushika, Akihito Saito, Shun Minatsuki, Hironobu Kikuchi, Arihiro Kiyosue, Yasutomi Higashikuni, M.D., Ph.D., FESC, Norifumi Takeda, Katsuhito Fujiu, Jiro Ando, Hiroshi Akazawa, Hiroyuki Morita, Issei Komuro (2021). Automatic detection of vessel structure by deep learning using intravascular ultrasound images of the coronary arteries. PLoS One. 2021 Aug 5;16(8):e0255577.

Kimie Tanaka, Daiju Fukuda, Yasutomi Higashikuni, M.D., Ph.D., FESC, Yoichiro Hirata, Issei Komuro, Toshiki Saotome, Yoshihiro Yamashita, Tetsuo Asakura, Masataka Sata (2020). Biodegradable Extremely-Small-Diameter Vascular Graft Made of Silk Fibroin can be Implanted in Mice. J Atheroscler Thromb. 2020 Dec 1;27(12):1299-1309.

Yasutomi Higashikuni, M.D., Ph.D., FESC (2020). Next-Generation Therapeutic Platforms in Cardiovascular Medicine. Masui. 2020 Nov;69:S146-S155..

Takuya Matsumoto, Satoshi Kodera, Hiroki Shinohara, Hirotaka Ieki, Toshihiro Yamaguchi, Yasutomi Higashikuni, M.D., Ph.D., FESC, Arihiro Kiyosue, Kaoru Ito, Jiro Ando, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Issei Komuro (2020). Diagnosing Heart Failure from Chest X-Ray Images Using Deep Learning. Int Heart J. 2020 Jul 30;61(4):781-786.

Project Project DOI

Yasutomi Higashikuni, M.D., Ph.D., FESC, Timothy K. Lu (2019). Advancing CRISPR-Based Programmable Platforms beyond Genome Editing in Mammalian Cells . ACS Synth Biol. 2019 Dec 20;8(12):2607-2619.

Project Project DOI

Kunduziayi Aini, Daiju Fukuda, Kimie Tanaka, Yasutomi Higashikuni, M.D., Ph.D., FESC, Yoichiro Hirata, Shunsuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata (2019). Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice. Int Heart J. 2019 Nov 30;60(6):1421-1429.

Fahim Farzadfard, Nava Gharaei, Yasutomi Higashikuni, M.D., Ph.D., FESC, Giyoung Jung, Jicong Cao, Timothy K. Lu (2019). Single-Nucleotide-Resolution Computing and Memory in Living Cells. Mol Cell. 2019 Aug 22;75(4):769-780.e4.

Project Project DOI

Sachiko Nishimoto, Kunduziayi Aini, Daiju Fukuda, Yasutomi Higashikuni, M.D., Ph.D., FESC, Kimie Tanaka, Yoichiro Hirata, Shunsuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Masataka Sata (2019). Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia. Front Cardiovasc Med. 2018 Oct 16;5:144.

Marcelo D. T. Torres, Cibele N. Pedron, Yasutomi Higashikuni, M.D., Ph.D., FESC, Robin M. Kramer, Marlon H. Cardoso, Karen G. N. Oshiro, Octavio L. Franco, Pedro I. Silva Junior, Fernanda D. Silva, Vani X. Oliveira Junior, Timothy K. Lu, Cesar de la Fuente-Nunez (2018). Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates. Commun Biol. 2018 Dec 7;1:221.

Yasutomi Higashikuni, M.D., Ph.D., FESC, William C.W. Chen, Timothy K. Lu (2017). Advancing therapeutic applications of synthetic gene circuits. Curr Opin Biotechnol. 2017 Oct;47:133-141.

Project Project DOI

Sachiko Nishimoto, Daiju Fukuda, Yasutomi Higashikuni, M.D., Ph.D., FESC, Kimie Tanaka, Yoichiro Hirata, Chie Murata, Joo-Ri Kim-Kaneyama, Fukiko Sato, Masahiro Bando, Shunsuke Yagi, Takeshi Soeki, Tetsuya Hayashi, Issei Komuro, Hiroshi Sakaue, Michio Shimabukuro, Masataka Sata (2016). Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance. Sci Adv. 2016 Mar 25;2(3):e1501332.

Yu Shimizu, Yoshifumi Itoda, Yasutomi Higashikuni, M.D., Ph.D., FESC, Yuri Kadowaki, Aya Saito, Hideo Fujita, Hiroshi Yamashita, Masafumi Watanabe, Minoru Ono, Issei Komuro (2015). Giant left atrial myxoma that caused mitral valve obstruction and pulmonary hypertension. Int J Cardiol. 2015 Nov 15;199:38-9.

Aiko Sakamoto, Yasutomi Higashikuni, M.D., Ph.D., FESC, Makiko Hongo, Yasushi Imai, Kazuhiko Koike, Ryozo Nagai, Issei Komuro, Nobukazu Ishizaka (2015). Pioglitazone Reduces Vascular Lipid Accumulation in Angiotensin II-Induced Hypertensive Rat. J Atheroscler Thromb. 2015;22(12):1225-34.

Hironori Muraoka, Yasutomi Higashikuni, M.D., Ph.D., FESC, Jiro Ando, Issei Komuro (2014). Cardiac compression by massive mediastinal haematoma due to bleeding from the ectopic bronchial artery. Eur Heart J. 2014 Jun 14;35(23):1567.

Yoichiro Hirata, Hirotsugu Kurobe, Mayuko Higashida, Daiju Fukuda, Michio Shimabukuro, Kimie Tanaka, Yasutomi Higashikuni, M.D., Ph.D., FESC, Tetsuya Kitagawa, Masataka Sata (2013). HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9. Atherosclerosis. 2013 Dec;231(2):227-33.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Kimie Tanaka, Megumi Kato, Osamu Nureki, Yasunobu Hirata, Ryozo Nagai, Issei Komuro, Masataka Sata (2013). Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1β upregulation via nuclear factor κB activation. J Am Heart Assoc. 2013 Nov 18;2(6):e000267.

Tatsuya Asanuma, Yasutomi Higashikuni, M.D., Ph.D., FESC, Hiroshi Yamashita, Ryozo Nagai, Toshiaki Hisada, Seiryo Sugiura (2013). Discordance of the areas of peak wall shear stress and tissue stress in coronary artery plaques as revealed by fluid-structure interaction finite element analysis: a case study. Int Heart J. 2013;54(1):54-8.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Julie Sainz, Kazuto Nakamura, Minoru Takaoka, Soichiro Enomoto, Hiroshi Iwata, Kimie Tanaka, Makoto Sahara, Yasunobu Hirata, Ryozo Nagai, Masataka Sata (2012). The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):654-61.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Minoru Takaoka, Hiroshi Iwata, Kimie Tanaka, Yasunobu Hirata, Ryozo Nagai, Masataka Sata (2012). Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice. Hypertens Res. 2012 Jan;35(1):62-9.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Julie Sainz, Kazuto Nakamura, Minoru Takaoka, Soichiro Enomoto, Hiroshi Iwata, Makoto Sahara, Kimie Tanaka, Nobutaka Koibuchi, Sumito Ito, Hiroyuki Kusuhara, Yuichi Sugiyama, Yasunobu Hirata, Ryozo Nagai, Masataka Sata (2010). The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function. Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2128-35.

S. Jono, S. Otsuki, Yasutomi Higashikuni, M.D., Ph.D., FESC, A. Shioi, K. Mori, K. Hara, H. Hashimoto, Y. Ikari (2010). Serum osteoprotegerin levels and long-term prognosis in subjects with stable coronary artery disease . J Thromb Haemost. 2010 Jun;8(6):1170-5.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Kengo Tanabe, Shuzou Tanimoto, Jiro Aoki, Hirosada Yamamoto, Gaku Nakazawa, Ruri Chihara, Yoshinobu Onuma, Shuji Otsuki, Atsuhiko Yagishita, Sen Yachi, Hiroyoshi Nakajima, Kazuhiro Hara (2009). Difference of culprit plaque composition between patients with and without pre-infarction angina: an intravascular ultrasound radiofrequency analysis. EuroIntervention. 2009 Aug;5(3):363-9.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Tamon Nagashima, Nobukazu Ishizaka, Koichiro Kinugawa, Yasunobu Hirata, Ryozo Nagai (2008). Right aortic arch with mirror image branching and vascular ring. Int J Cardiol. 2008 Oct 30;130(1):e53-5.

Kazuto Nakamura, Nobutaka Koibuchi, Hiroaki Nishimatsu, Yasutomi Higashikuni, M.D., Ph.D., FESC, Yasunobu Hirata, Kiyotaka Kugiyama, Ryozo Nagai, Masataka Sata (2008). Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice. Hypertens Res. 2008 Oct;31(10):1953-61.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Kengo Tanabe, Shuzou Tanimoto, Jiro Aoki, Hirosada Yamamoto, Gaku Nakazawa, Ruri Chihara, Yoshinobu Onuma, Shuji Ohtsuki, Atsuhiko Yagishita, Sen Yachi, Hiroyoshi Nakajima, Kazuhiro Hara (2008). Impact of culprit plaque composition on the no-reflow phenomenon in patients with acute coronary syndrome: an intravascular ultrasound radiofrequency analysis. Circ J. 2008 Aug;72(8):1235-41.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Nobukazu Ishizaka, Yuko Ishizaka, EiIchi Toda, Ryozo Nagai, Minoru Yamakado (2008). Relationship between blood pressure and chronic kidney disease in the Japanese population: the lower the better even in individuals without hypertension?. Hypertens Res. 2008 Feb;31(2):213-9.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Masaya Mori, Hiroyoshi Kino (2007). Interleukin-6-producing giant cell carcinoma of the lung with multicentric Castleman's disease-like presentation. Intern Med. 2007;46(10):669-73.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Kengo Tanabe, Hirosada Yamamoto, Jiro Aoki, Gaku Nakazawa, Yoshinobu Onuma, Shuji Otsuki, Atsuhiko Yagishita, Sen Yachi, Hiroyoshi Nakajima, Kazuhiro Hara (2007). Relationship between coronary artery remodeling and plaque composition in culprit lesions: an intravascular ultrasound radiofrequency analysis. Circ J. 2007 May;71(5):654-60.

Yasutomi Higashikuni, M.D., Ph.D., FESC, Masataka Sata, Ryozo Nagai (2005). Reversible left ventricular hypertrophy after tako-tsubo-like cardiomyopathy. Acta Cardiol. 2005 Feb;60(1):77-9.