Just published in Circulation!!
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
Neural Control of Cardiac Inflammation
Inflammation is involved in the pathophysiology of cardiac remodeling and hypertrophy. However, very little is known about the mechanism that controls cardiac inflammation and hypertrophy. In this study, we demonstrated that neural signals control cardiac inflammation and hypertrophy through NLRP3 inflammasome activation and IL-1beta production during pressure overload. https://www.ahajournals.org/doi/abs/10.1161/CIRCULATIONAHA.122.060860
Yasutomi Higashikuni, M.D., Ph.D., FESC
Assistant Professor of Cardiovascular and Genetic Research
My research interests include homeostatic inflammation, RNA metabolism and modification, and synthetic biology.